Doxycycline is one of the time-tested antibiotics. It was synthesized in the early 60s of the last century by scientists of the American pharmaceutical giant Pfizer. The drug was clinically studied and released under the trade name Vibramycin.
A little later, the World Health Organization included Doxycycline in the list of the most important medicines needed for human health. It would seem that the development of the pharmaceutical industry and the production of new broad-spectrum antibiotics does not leave the chance of survival to such “old people” as Doxycycline. However, it is not. And the fact that the drug actually found its niche is an indisputable fact. What this antibiotic has provided for so long a life? What side effects should be feared? In this article we will try to understand the properties of Doxycycline.
Composition and form of release So, Doxycycline is a semisynthetic antibacterial drug from the group of tetracyclines. Doxycycline derivatives: monohydrate, hydrochloride and calcium salt are active in relation to microorganisms and chemical stability. It is these three compounds that are used as active substances. Oral Doxycycline is available in capsules and tablets of 100 and 200 mg. Parenterally, that is, intramuscularly or intravenously, this antibiotic is not used.
Indications for use
A wide spectrum of action of Doxycycline allows using it for the treatment of a large number of infections, the causative agents of which are sensitive to this antibiotic: respiratory diseases (acute and chronic bronchitis, pneumonia, lung abscess and pleural empyema, pleurisy); urinary tract infection (urethritis, pyelonephritis); infection of the ENT organs (otitis, sinusitis or inflammation of the paranasal sinuses, tonsillitis); intestinal infections (dysentery, salmonellosis, typhoid fever, cholera and others); diseases of the pelvic organs in men and women (endometritis, salpingoophoritis, epididymitis, prostatitis); inflammatory diseases of the gastrointestinal tract (cholecystocholangitis, proctitis, peritonitis); infections of soft tissues and skin (furunculosis, carbuncle, acne); Sexually transmitted infections (syphilis primary and secondary, gonorrhea, ureaplasmosis, chlamydia); many infectious diseases (brucellosis, typhus, rickettsiosis, fever Ku, yersiniosis, borreliosis, tularemia, whooping cough, leptospirosis and others); eye diseases (trachoma, ulcerative keratitis); osteomyelitis, etc.
Instructions for use Doxycycline
Doxycycline is available in the form of capsules intended for oral administration and as a solution for injection. The use of Doxycycline in the form of capsules should be performed after meals, washed down with water to prevent possible irritation of the esophagus. The daily dose is taken either once every 24 hours, or twice with an interval of 12 hours. Most infections involve taking 200 mg of Doxycycline on the first day of treatment and 100-200 mg on subsequent days. Infections that provoked chlamydia, mycoplasma, ureaplasma, Doxycycline cures for 10-14 days. More severe forms of infections suggest taking 200 mg of Doxycycline throughout the course of treatment. In women, pelvic inflammatory disease is recommended to be treated by taking 2 times a day for 100 mg of the drug, in men – 2 times a day for 100 mg or once 300 mg. In medical abortion, 100 mg of Doxycycline is applied 1 hour before the operation, and after its completion in half an hour, another 200 mg. With syphilis apply Doxycycline, the instruction recommends for 10 days for 300 mg every 24 hours. Within 2-4 days of 100 mg 2 times a day take Doxycycline in gonorrhea. A single dose of 300 mg treats gonorrheal urethritis in men, but if the expected effect is not obtained, men continue to take Doxycycline for 4 days for 200 mg and women for one day longer.