Properties and functions of Exemestane:
Exemestane is officially classed as a steroid “suicidal” Aromatase Inhibitor, which has the ability to inhibit the aromatase enzyme, which is responsible for producing and converting testosterone to estrogen. Aromasine has the property of blocking the aromatization, which in turn inhibits the production of estrogen, thereby lowering the levels of estrogen in the serum of the body. This proves its effectiveness in the treatment of breast cancer, since it is associated with increased estrogen. For the same reason, the drug will be useful to consumers of anabolic steroids.
Many anabolic steroids have the ability to increase estrogen levels during aromatization, in particular, converting testosterone to estrogen. Which leads to gynecomastia and water retention. Excessive water retention, in severe forms, can also cause increased blood pressure. Steroids that do not have strong estrogenic properties may also cause such effects, especially gynecomastia, if they have progestin properties. A striking example is Nadrolol, which only aromatizes 20% of testosterone. However, it has strong progestin properties, and progesterone has been noted to realize the possibility of stimulating the estrogenic mechanism in the tissues of the mammary glands. Taking Exemestane during the course of anabolic steroids, it will inhibit the aromatization process by lowering estrogen levels, and protecting the individual from side effects from estrogen. How effective is Exemestane? It is claimed that the product has the ability to lower serum estrogen levels by 85%.
Exemestane also has the property of stimulating the production of natural testosterone, which is why some include this drug during PKT. Like Arimidex and Letrozole, Exemestane signals the pituitary gland to produce Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH), two hormones needed to produce natural testosterone. Other IAs also have this property, but Exemestane has demonstrated a small androgenic effect, as well as the ability to increase the production of the Insulin-like growth factor-1 (IGF-1). This property is not in any IA. Taking Exemestane during PCT, a person gets the necessary testosterone charge for recovery, but the increase in IGF-1 creates a strong anabolic atmosphere. Some consumers of steroids find this useful, since it gives them the opportunity to protect their muscle tissue at the time of taking. However, if we consider the direct consequences of taking Exemestane during PCT, it will be found that it is not recommended for PCT, despite its positive effects.
Exemestane and Tamoxifen
Exemestane has a neutral effect on total cholesterol and HDL. Unlike the positive effect of tamoxifen on LDL, exemestane does not significantly change LDL levels. Tamoxifen also increases the concentration of triglycerides, and exemestane leads to a positive reduction in TSH levels. These data also relate to the safety and tolerability of exemestane in postmenopausal women with breast cancer and will be of great help in further studies and in adjuvant therapy.
Exemestane (aromazine) has been used for many years in the treatment of common hormone-positive breast cancer in postmenopausal women. In October 2005, the US Food and Drug Administration (FDA) approved the use of exemestane as an adjuvant therapy in patients with early breast cancer.
In one study, involving 5,000 postmenopausal women with early hormone-positive breast cancer, tamoxifen was taken for 2 to 3 years. Approximately half of them were later transferred to exemestans, which they took for another 2 to 3 years (total 5 years of hormonal therapy). The remaining patients continued to take tamoxifen all this time. At the same time, researchers drew attention to the risk of developing cancer recurrence in each group of women, the risk of developing a new cancer in another mammary gland and what was the period of the patient’s life without relapse in each group.
Funny phrase from the forum: “I found the best way to regulate the levels of estradiol – this is measured by a ruler member at night and in the morning. With a good level of estradiol, there will be such a killer potency that you can use a member instead of a coat hanger. “
Dosage is individual, which is true for steroids, as well as for the antiestrogen or aromatase inhibitor. It also depends on other indicators, such as sex, type and duration of the course, height / weight, etc. A moderate course is 12.5 mg of aromazine twice a week, which is enough to regulate estrogen levels and increase total testosterone.
– After 120 hours – return to the initial state (no effect), which means: you can find a more effective dosage for yourself. Some advise taking 25 mg of ED (every day) and 12.5 mg of E4D. These numbers work equally effectively, providing suppression of various levels of estrogen.
Exemestane can cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- muscle or joint pain
- Difficulty falling asleep or sleeping
- hair loss
- red, itchy skin
- changes in vision
Some side effects can be severe. If you experience any of these symptoms, consult your doctor:
- labored breathing
- chest pain
Aromex (Alpha Pharma)£70.50